Hindsight in 2020: Navigating a new normal with SARS-CoV2
Some work I did during the pandemic while we were pondering the airborne transmission of the virus, unfortunately, never got published.
Tag: Research Article
Lymphoid follicles in chronic lung diseases
Koshika Yadava, Benjamin J Marsland Abstract Lymphoid follicles (LFs) can be induced in the lung on infection or chronic inflammation; however, their relevance and contribution to protective immunity or pathogenesis is poorly understood. Recent advances from clinical studies and animal models have shed some light on the mechanisms that trigger and facilitate the development of
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The airway microbiome and disease
Benjamin J Marsland , Koshika Yadava , Laurent P Nicod Abstract Although traditionally thought to be sterile, accumulating evidence now supports the concept that our airways harbor a microbiome. Thus far, studies have focused upon characterizing the bacterial constituents of the airway microbiome in both healthy and diseased lungs, but what perhaps provides the greatest impetus for the exploration
The formation and function of tertiary lymphoid follicles in chronic pulmonary inflammation
Koshika Yadava, Paul Bollyky, Melissa A. Lawson Summary Tertiary lymphoid follicles (TLFs) can develop in the respiratory tract in response to infections or chronic inflammation. However, their functional relevance remains unclear because they are implicated in both protective and pathological responses. In contrast to homeostatic conditions, external antigens and damage to the lung tissue may drive TLF
Natural Tr1-like cells do not confer long-term tolerogenic memory
Koshika Yadava # 1 2, Carlos Obed Medina # 1, Heather Ishak 1, Irina Gurevich 1, Hedwich Kuipers 1 3, Elya Ali Shamskhou 1, Ievgen O Koliesnik 1, James J Moon 4 5, Casey Weaver 6, Kari Christine Nadeau 7, Paul L Bollyky 1 PMID: 31603425 PMCID: PMC6788856 DOI: 10.7554/eLife.44821 Abstract IL-10-producing Tr1 cells promote tolerance but their contributions to tolerogenic memory are unclear. Using 10BiT mice that carry a Foxp3-eGFP reporter and stably express CD90.1 following IL-10 production, we characterized
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