Lab

My research questions and experiments were shaped by the structures within which the lab operated. In the biotech and Pharma industries, these questions focused on diseases and the market: How do we design gene therapies to efficiently package therapeutic payloads, ensuring precise and effective expression? What could we patent? What novel targets can we identify to reduce disease exacerbations? Does our approach have a competitive edge?

In academia, my questions focused on how the immune system functions at barrier sites. What are the site-specific cues to the behaviour of resident immune cells? Who do they interact with, and how does their interplay with the extracellular matrix differ? Where does the microbiome feature in these behaviours? Could I publish this work in a high-impact paper ? Would these questions titillate the grant reviewers?

I am not certain I unravelled many mysteries, but I did gain an incredible appreciation for the plurality of our existence, the complexities of our interactions within our bodies and the world beyond, and an eagle-eyed view of the problems of reductionism in science. The latter became a springboard for my entanglements with art.

Selected publications

2024 Zenke F, Yadava K. A brief primer on artificial intelligence — The technological advances behind the smart devices in our lives. Book Chapter Robots and Gadgets, ageing at home. Edited by: Félix Pageau, Tenzin Wangmo
and Emilian Mihailov

2020 Chen YL, Hardman CS, Yadava K, Ogg G. Novel innate lymphocyte mechanisms in skin diseases. Annual Reviews in Immunology

2019 Yadava K*, Medina C, Ishak H, Gurevich I, Kuipers H, Shamskou E, Nadeau K, Bollyky P, Naturally arising Tr1-like cells do not confer lasting tolerance to airway allergens.eLife *Corresponding author

2016 Yadava K*, Bollyky P, Lawson MA. The formation and function of tertiary lymphoid follicles in chronic pulmonary inflammation. Immunology *Corresponding and senior author

2015 Yadava K*, Pattaroni C, Sichelstiel AK, Trompette A, Gollwitzer ES, Salami O,von Garnier C, Nicod LP, Marsland BJ. Microbiota Promotes Chronic Pulmonary Inflammation by Enhancing IL-17A and Autoantibodies. Am J Respir Crit Care Med*Corresponding author

2014 Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, Blanchard C, Junt T, Nicod LP, Harris NL, Marsland BJ. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis.Nat Med

2013 Yadava K, Sichelstiel A, Luescher IF, Nicod LP, Harris NL, Marsland BJ. TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function. Mucosal Immunol

2014 Yadava K, Marsland BJ. IL-4Rα, a STUB-strate for proteasomal degradation:understanding the termination of cytokine signaling in asthma. Am J Respir Crit Care Med

Full list of publications is here.

Something I did out of interest during the pandemic, but never published is below: